Evaluation of normalization methods for the Standardized Uptake Value in Bone SPECT/CT

1803 Objectives: :Standardized uptake value (SUV) normalized by lean body mass is recommended by positron emission tomography response criteria in solid tumors (PERCIST) to reduce the dependency of body weight in 18F-FDG PET/CT. In this study, the dependency of body weight in SUV values were evaluated for each of normalization methods in bone SPECT/CT. Methods:99mTc-(H)MDP bone SPECT/CT was conducted with the use of Symbia Intevo (Siemens Healthcare, Erlangen, Germany). Patients who were not identified as having any bone metastases were retrospectively reviewed on 237 cancer patients (117 men, 120 women). SUV-mean values of the first lumbar vertebrae (L1) were measured in spheroidal volume-of-interest (2.41cm3), using a vender-neutral software GI-BONE (AZE, Tokyo, Japan). The SUV-mean values were calculated by normalization parameters using body weight (SUV-bw), lean body mass (SUV-lbm), Japanese lean body mass (SUV-Jlbm), body surface area (SUV-bsa), and bone mineral (SUV-bone). The Pearson’s correlation coefficient between body weight and each of SUVs were analyzed. Results:The correlation coefficients in each of SUVs(SUV-bw, SUV-lbm, SUV-Jlbm, SUV-bsa, SUV-bone) were (r=0.235(p