医学
狭窄
鼻咽癌
放射治疗
入射(几何)
颈内动脉
内科学
颈总动脉
颈动脉
放射科
心脏病学
光学
物理
作者
Wang Liao,Yuqiu Zheng,Shangqing Bi,Bei Zhang,Ying Xiong,Yi Li,Wenli Fang,Shifu Xiao,Liguo Yang,Thea Anderson,Jun Li
标识
DOI:10.1016/j.radonc.2018.11.013
摘要
Radiotherapy (RT) is the most effective treatment for nasopharyngeal carcinoma (NPC) but may cause stenosis of the carotid arteries. This meta-analysis evaluates the prevalence of carotid stenosis after radiation therapy.Online search for studies reporting carotid stenosis in patients with NPC who received radiation therapy (RT) compared to NPC patients who did not receive RT and compared to healthy controls.Twelve studies were included for a total analysis of 1928 patients (837 received RT and 1091 were controls). RT patients showed a statistically significant higher incidence of overall stenosis (pooled risk ratio = 4.17 [2.44, 7.10], p < 0.00001) and an even greater incidence of significant stenosis (50% or more) (pooled risk ratio = 8.72 [3.53, 21.55], p < 0.00001). Analyzing by individual blood vessels showed that the RT patients had significantly higher incidence of stenosis in common carotid artery (CCA), external carotid artery (ECA), carotid bulb, CCA and internal carotid artery (ICA), and CCA/ICA/carotid bulb.NPC patients who receive RT have increased risk of developing carotid stenosis, and should be screened after treatment.
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