Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

Abstract Homochiral metal–organic frameworks (MOFs) have gained much attention because of their chiral properties and disposition for chiral separation. However, the fabrication of high‐quality homochiral MOF membranes remains challenging because of the difficulty in controlling growth of MOF membranes with chiral functionalities. A homochiral zeolitic imidazolate framework‐8 (ZIF‐8) membrane is reported for efficient chiral separation. The membrane is synthesized by incorporating a natural amino acid, l ‐histidine ( l ‐His), into the framework of ZIF‐8. The homochiral l ‐His‐ZIF‐8 membrane exhibits a good selectivity for the R ‐enantiomer of 1‐phenylethanol over the S ‐enantiomer, showing a high enantiomeric excess value up to 76 %.