Inhibition of vibrio parahaemolyticus by polyphenol compounds from carageen by plate growth inhibition tested to observe its bacteriostasis effect on V.parahaemolyticus. The test results show that within a certain range, polyphenols from carageen have obvious antibacterial activity against V.parahaemolyticus, the size of antibacterial activity is closely related to polyphenol concentration and molecular mass.The higher the content of polyphenols, the stronger the bacteriostasis it has. It indicates that carageen polyphenol compounds can inhibit V.parahaemolyticus.