Notch信号通路
生物
Wnt信号通路
转录因子
细胞生物学
Notch蛋白质类
Hes3信号轴
调节器
机制(生物学)
信号转导
细胞命运测定
细胞周期蛋白依赖激酶8
跨膜蛋白
抄写(语言学)
遗传学
受体
基因
认识论
哲学
语言学
作者
Peter Andersen,Hideki Uosaki,Lincoln T. Shenje,Chulan Kwon
标识
DOI:10.1016/j.tcb.2012.02.003
摘要
Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.
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