Asymmetric Self‐ and Cross‐Aldol Reactions of Glycolaldehyde Catalyzed by D‐Fructose‐6‐phosphate Aldolase

New facets of enzyme activity: D-Fructose-6-phosphate aldolase (FSA) catalyzes the self-aldol reaction of glycolaldehyde (GA) and its cross-aldol addition to other aldehydes. As the affinity of GA for FSA as a donor is higher than that as an acceptor, cross-aldol reactions are possible with good to poor aldehyde acceptors if the concentration of GA in the reaction is kept low.