细菌
金黄色葡萄球菌
大肠杆菌
表皮葡萄球菌
溴化物
接触角
化学
细菌生长
水溶液
共价键
细菌细胞结构
微生物学
核化学
葡萄球菌
假单胞菌
铜绿假单胞菌
材料科学
有机化学
生物化学
生物
复合材料
基因
遗传学
作者
Joerg C. Tiller,Chun Yen Liao,Kim Lewis,Alexander M. Klibanov
标识
DOI:10.1073/pnas.111143098
摘要
Poly(4-vinyl- N -alkylpyridinium bromide) was covalently attached to glass slides to create a surface that kills airborne bacteria on contact. The antibacterial properties were assessed by spraying aqueous suspensions of bacterial cells on the surface, followed by air drying and counting the number of cells remaining viable (i.e., capable of growing colonies). Amino glass slides were acylated with acryloyl chloride, copolymerized with 4-vinylpyridine, and N -alkylated with different alkyl bromides (from propyl to hexadecyl). The resultant surfaces, depending on the alkyl group, were able to kill up to 94 ± 4% of Staphylococcus aureus cells sprayed on them. A surface alternatively created by attaching poly(4-vinylpyridine) to a glass slide and alkylating it with hexyl bromide killed 94 ± 3% of the deposited S. aureus cells. On surfaces modified with N -hexylated poly(4-vinylpyridine), the numbers of viable cells of another Gram-positive bacterium, Staphylococcus epidermidis , as well as of the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli , dropped more than 100-fold compared with the original amino glass. In contrast, the number of viable bacterial cells did not decline significantly after spraying on such common materials as ceramics, plastics, metals, and wood.
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