医学
弥漫性大B细胞淋巴瘤
淋巴瘤
嵌合抗原受体
癌症研究
内科学
国际预后指标
美罗华
肿瘤科
T细胞
作者
Xin-Qi Zheng,Chongyang Ding,Yi-Xin Zou,Hua-Yuan Zhu,Li Wang,Lei Fan,Wei Xu,Jianyong Li
出处
期刊:Journal of Experimental Hematology
日期:2020-08-01
卷期号:28 (4): 1189-1196
标识
DOI:10.19746/j.cnki.issn.1009-2137.2020.04.018
摘要
Objective To investigate the prognosis prediction value of PET/CT in DLBCL patients treated with CAR-T therapy. Methods The effects of PET/CT were retrospectively explored on 13 R/R DLBCL patients who were treated with CAR-T therapy. Parameters reflecting tumor metabolic burden, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured before and after CAR-T treatment. Results Patients with larger baseline MTV or longer sum of longest diameters showed shorter overall survival (OS) time than those with low tumor burden. Patients achieved complete remission (CR), partial remission (PR) and minor remission (MR) determined by response evaluation criteria in lymphoma (RECIL) in 12 weeks showed progression-free survival and OS time superior to those of patients with no remission. In addition, it was found that 2 patients with residual masses classified as PR by contrast-enhanced CT of patients were evaluated as complete metabolic response by PET/CT imaging. Conclusion PET/CT shows a great value in the evaluation of prognosis and response in CAR-T-treated R/R DLBCL patients.
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