广州管圆线虫
上睑下垂
炎症体
NLRC4型
目标2
吡喃结构域
半胱氨酸蛋白酶1
脑膜脑炎
生物
免疫学
半胱氨酸蛋白酶
炎症
细胞凋亡
程序性细胞死亡
生物化学
蠕虫
作者
Ho Yin Pekkle Lam,Tina Tu Wen Chen,Cheng Chi Chen,Ting Yang,Po Ching Cheng,Shih-Yi Peng
标识
DOI:10.1016/j.parint.2020.102119
摘要
Angiostrongylus cantonensis is a metastrongyloid nematode that causes eosinophilic meningoencephalitis in humans. A high infestation of A. cantonensis can cause permanent brain damage or even death. The inflammasome is an oligomeric molecular platform that can detect microbial pathogens and activate inflammatory cytokines. The recognition of larval surface antigens by pattern recognition receptors (PRRs) can cause oligomerization of the NOD-like receptor (NLR) or absent in melanoma 2 (AIM2) with the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) to form a caspase-1-activating scaffold. Activated caspase-1 converts pro-inflammatory cytokines into their mature, active forms. Helminths infection has been shown to activate NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasomes. In this study, we aimed to investigate the mechanism of inflammasome activation upon A. cantonensis infection in a mouse model. This study provides evidence that A. cantonensis infection can activate NLRP1B and NLRC4 inflammasomes and promote pyroptosis to cause meningoencephalitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI