Design, Synthesis, and Biological Evaluation of New Indole-Acrylamide-1,2,3-Triazole Derivatives as Potential α-Glucosidase Inhibitors

In this work, new indole-acrylamide-1,2,3-triazole derivatives 9a–j were synthesized via simple and efficient chemical reactions and screened for in vitro anti-α-glucosidase activities. All the synthesized derivatives exhibited excellent α-glucosidase inhibition in the range of IC50 = 65.0 ± 0.8 − 396.3 ± 0.7 µM as compared to the standard inhibitor acarbose (IC50 = 750.0 ± 1.5 µM). Furthermore, kinetic, docking, and toxicity evaluation of the title compounds were also performed.