New gastroretentive medication delivery method using in situ gel

Due to their rapid elimination from the stomach and duodenum, liquid dose forms are more likely tohave poor bioavailability than other oral dosage forms. A liquid in-situ gelling device might be aneffective way to increase the production of a sustained release formulation of an oral liquidformulation. Gels may be formed in response to variations in temperature, pH, ionic strength, andultraviolet light, all of which influence the rate and duration of drug release. Advantages of in situ gelforming polymeric formulations include increased bioavailability of medicine and patient compliancevia decreased dose frequency, as well as sustained and extended activity in contrast to traditional drugdelivery methods.