初乳
母乳喂养
免疫系统
保健品
母乳喂养
生物
2019年冠状病毒病(COVID-19)
免疫衰老
病毒
表位
糖基化
医学
免疫学
抗体
内科学
食品科学
儿科
疾病
遗传学
传染病(医学专业)
作者
Jiao Guo,Minjie Tan,Jing Zhu,Ye Tian,Huanyu Liu,Fengguang Luo,Jianbin Wang,Yanyi Huang,Yuanzhen Zhang,Yuexin Yang,Guanbo Wang
出处
期刊:Nutrients
[MDPI AG]
日期:2022-06-17
卷期号:14 (12): 2513-2513
被引量:3
摘要
Despite the well-known benefits of breastfeeding and the World Health Organization's breastfeeding recommendations for COVID-19 infected mothers, whether these mothers should be encouraged to breastfeed is under debate due to concern about the risk of virus transmission and lack of evidence of breastmilk's protective effects against the virus. Here, we provide a molecular basis for the breastfeeding recommendation through mass spectrometry (MS)-based proteomics and glycosylation analysis of immune-related proteins in both colostrum and mature breastmilk collected from COVID-19 patients and healthy donors. The total protein amounts in the COVID-19 colostrum group were significantly higher than in the control group. While casein proteins in COVID-19 colostrum exhibited significantly lower abundances, immune-related proteins, especially whey proteins with antiviral properties against SARS-CoV-2, were upregulated. These proteins were detected with unique site-specific glycan structures and improved glycosylation diversity that are beneficial for recognizing epitopes and blocking viral entry. Such adaptive differences in milk from COVID-19 mothers tended to fade in mature milk from the same mothers one month postpartum. These results suggest that feeding infants colostrum from COVID-19 mothers confers both nutritional and immune benefits, and provide molecular-level insights that aid breastmilk feeding decisions in cases of active infection.
科研通智能强力驱动
Strongly Powered by AbleSci AI