Photo‐Activated Nanofibrous Membrane with Self‐Rechargeable Antibacterial Function for Stubborn Infected Cutaneous Regeneration

Abstract For quick disinfection treatment, phototherapy, including photothermal therapy and photodynamic therapy, has emerged as a promising alternative to conventional methods. However, the bactericidal effect of phototherapy, which only works upon light, is short‐lived. The remaining bacteria in situ may repopulate when the irradiation of light is withdrawn. To address this refractory concern, an antibacterial fibrous membrane consisting of electrospun poly (polycaprolactone) scaffolds and polydopamine (pDA) coated MXene/Ag 3 PO 4 bioheterojunctions (MX@AgP bio‐HJs) is devised and developed. Upon near‐infrared (NIR) illumination, the MX@AgP nanoparticle (NP) in nanofibrous electrospun membranes exert the excellent bactericidal effect of phototherapy and release Ag + ions which stop the remaining bacteria from multiplying in the dark state. When removing NIR light, pDA in situ reduces Ag + ions to Ag 0 NPs to realize the self‐rechargeability of Ag + ions and provides enough Ag + ions for the second phototherapy. In vivo results show that photoactivated nanofibrous membranes can re‐shape an infected wound microenvironment to the regenerative microenvironment through killing bacteria, ceasing bleeding, increasing epithelialization, and collagen deposition on the wound bed, as well as promoting angiogenesis. As predicted, the proposal work offers potential prospects for nanofibrous membranes with NIR‐assisted “self‐rechargeable” antibacterial properties to treat bacteria‐infected full‐thickness wounds.