二肽酶
肾
酶
化学
微粒体
生物化学
西司他丁
酶抑制剂
药理学
生物
内分泌学
抗生素
抗生素耐药性
亚胺培南
作者
Manfred Köller,J. Brom,Monika Raulf,Wolfgang König
标识
DOI:10.1016/0006-291x(85)91335-x
摘要
The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. The comparison with similar enzyme activities from other tissues (liver, lung, serum, polymorphonuclear granulocytes) revealed a high specifity of cilastatin for the kidney enzyme which was found to be associated with the microsomal fraction. The lowest detectable inhibitory concentration of cilastatin within renal tissue was 8 × 10−8M.
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