医学
人体测量学
肥胖
风险因素
早晨
昼夜节律
人口
内科学
代谢综合征
接收机工作特性
环境卫生
作者
M. D. Corbalán-Tutau,Puri Gómez-Abellán,Juan Antonio Madrid,Manuel Canteras,José M. Ordovás,Marta Garaulet
标识
DOI:10.1016/j.clnu.2014.05.007
摘要
Background & aims To test several circadian rhythm variables in a female population to identify the best tool to assess chronodisruption in obesity and metabolic syndrome (MetS) to define a score to be used for chronodisruption characterization in clinical practice. Methods Anthropometric measurements and markers of circadian rhythms, such as sleep and feeding diary, Horne–Ostberg questionnaire, melatonin and cortisol measurements, and wrist temperature measurements, were determined. MetS variables were also analyzed. Study was conducted in 70 women. Data were subjected to factor analysis. Receiver operating characteristic curves were used as predictors of chronodisruption risk, and a score was calculated to classify the subjects of risk. Results Factor analysis showed that the first-factor grouped variables were related to the skin temperature measurement. Second factor consisted of variables related to salivary cortisol levels and obesity-related measurements. Third factor included variables related to sleep-wake cycle. Fourth factor referred to peripheral temperature variables and included the classification of subjects according to the Horne–Ostberg questionnaire. To obtain a final punctuation we performed the weighted mean of the first four factors. The final range was from 27 to 57, mean value of 42. Punctuation was defined as the “chronodisruption score.” Women displaying higher chronodisruption scores had higher MetS risk. Conclusion The study demonstrates that wrist temperature recordings, together with two questions of sleep onset and offset, and one morning salivary cortisol determination could be enough to characterize the chronobiology of obesity and MetS, a new chronodisruption score was developed.
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