Subjective and physiologie effects of intravenous buprenorphine in humans

Clinical Pharmacology & TherapeuticsVolume 53, Issue 5 p. 570-576 Pharmacodynamics and Drug Action Subjective and physiologie effects of intravenous buprenorphine in humans Wallace B Pickworth PhD, Wallace B Pickworth PhD National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorRolley E Johnson PharmD, Rolley E Johnson PharmD National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorBarbara A Holicky RN, Barbara A Holicky RN National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorEdward J Cone PhD, Corresponding Author Edward J Cone PhD National Institute on Drug Abuse, Addiction Research CenterEdward J Cone PhD Clinical Pharmacology Branch, NIDA, Addiction Research Center, P.O. Box 5180, Baltimore, MD 21224.Search for more papers by this author Wallace B Pickworth PhD, Wallace B Pickworth PhD National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorRolley E Johnson PharmD, Rolley E Johnson PharmD National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorBarbara A Holicky RN, Barbara A Holicky RN National Institute on Drug Abuse, Addiction Research CenterSearch for more papers by this authorEdward J Cone PhD, Corresponding Author Edward J Cone PhD National Institute on Drug Abuse, Addiction Research CenterEdward J Cone PhD Clinical Pharmacology Branch, NIDA, Addiction Research Center, P.O. Box 5180, Baltimore, MD 21224.Search for more papers by this author First published: May 1993 https://doi.org/10.1038/clpt.1993.72Citations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The pharmacologie profile of sublingual and subcutaneous buprenorphine, a partial opioid agonist, indicates it may be useful as a maintenance drug in the treatment of opioid dependence. However, illicit intravenous self-administration suggests that it may have a greater abuse potential by this route of administration. Physiologic and subjective effects of intravenous buprenorphine (0.0, 0.3, 0.6, and 1.2 mg) were determined in a dose-escalation study in six nondependent volunteers with histories of opioid use. Buprenorphine caused miosis and decreased respiratory rate, increased diastolic blood pressure, and transiently increased heart rate. Buprenorphine increased positive responses on a "feel drug" question and scores on scales of "liking," "good effects," euphoria, and apathetic sedation. Physiologic and subjective responses were not consistently dose related, a finding compatable with the pharmacologie profile of a partial agonist. The findings indicate that buprenorphine has substantial potential for abuse when administered intravenously. Clinical Pharmacology and Therapeutics (1993) 53, 570–576; doi:10.1038/clpt.1993.72 Citing Literature Volume53, Issue5May 1993Pages 570-576 RelatedInformation