生物
肝细胞癌
连环蛋白
癌症研究
运动性
转移
信号转导
上皮-间质转换
恶性肿瘤
BETA(编程语言)
Wnt信号通路
细胞生物学
癌症
遗传学
计算机科学
程序设计语言
作者
Lei Liu,Jinsheng Wu,Shaochuang Wang,Xi Luo,Yemu Du,Dongfang Huang,Dianhua Gu,Feng Zhang
标识
DOI:10.1016/j.yexcr.2017.06.014
摘要
Over-activation of beta-catenin/TCF signaling has been frequently observed in hepatocellular carcinoma (HCC). Better understanding the molecular mechanism for the aberrant activation of beta-catenin/TCF signaling would provide novel insights into the treatment of this malignancy. In this study, we have shown that the expression of PKMYT1 was up-regulated in HCC. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition (EMT) of HCC cells. Mechanically, PKMTY1 activated the beta-catenin/TCF signaling by binding and inactivating GSK3beta. Taken together, our study demonstrated the oncogenic activity of PKMYT1 in the progression of HCC and suggested that PKMYT1 might be a therapeutic target.
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