生物
病毒学
病毒复制
病毒
病毒蛋白
病毒进入
特瑟林
基因
作者
Weiwei Dai,Yoshiko Usami,Yuanfei Wu,Heinrich G. Göttlinger
出处
期刊:Cell Reports
[Elsevier]
日期:2018-01-23
卷期号:22 (4): 869-875
被引量:34
标识
DOI:10.1016/j.celrep.2017.12.082
摘要
We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef. We now report that the anti-HIV-1 activity, but not the sensitivity to Nef, is conserved among vertebrate SERINC5 proteins. However, a Nef-resistant SERINC5 became Nef sensitive when its intracellular loop 4 (ICL4) was replaced by that of Nef-sensitive human SERINC5. Conversely, human SERINC5 became resistant to Nef when its ICL4 was replaced by that of a Nef-resistant SERINC5. In general, ICL4 regions from SERINCs that exhibited resistance to a given Nef conferred resistance to the same Nef when transferred to a sensitive SERINC, and vice versa. Our results establish that human SERINC5 can be modified to restrict HIV-1 infectivity even in the presence of Nef.
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