Objective To investigate the effect of nursing intervention on the psychology and quality of life in radiotherapy for patients with bone metastases. Methods Fifry-eight patients with bone metastases undergoing radiotherapy were randomly divided into the experimental group (nursing intervention group) and the control group (the traditional nursing group), with 29 patients in each group. Anxiety and depression were compared according to self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in two groups. Quality of life were compared according to the European Organization Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in two groups. Results The values of the experimental group by the intervention of anxiety and depression were (36.9± 2.4), (37.6±3.2), significantly lower than (41.8±3.2), (42.3±3.1) in the control group (P0.05). The two groups showed no statistically significant difference in marriage and family factors of the material life and social function (P0.05), but has statistically significant difference in the remaining factors (P0.05). Conclusion The nursing intervention reduces the anxiety and depression of patients, and improves their quality of life significantly.