Synthesis of oleanolic acid and glycyrrhetinic acid derivatives and the study of anti-cancer activities

Oleanolic acid and glycyrrhetinic acid belong to pentacyclic triterpenoid of natural products.They widely distributed in nature and show many bioactivities such as protect liver,anti-inflammatory,antibacterial,antiviral pharmacological.They also have good anti-cancer activity.So oleanolic acid and glycyrrhetinic acid were took as the lead compounds for modifying their structures in this paper.Fifteen kinds of intermediates and final products were synthesized through modification of oleanolic acid and glycyrrhetinic acid.These compounds were characterized by IR and 1H NMR techniques.The anti-cancer activity of some compounds were investigated against human cervical cancer cells(Hela) and human breast cancer cells(MCF—7).The results showed that the inhibit activities of two compounds are more significantl than lead compounds.