The pathological influence of antiangiogenesis gene therapy on hypertrophic scar

Objective To investigate the pathological influence of antiangiogenesis gene therapy on hypertrophic scar of rabbits' ears.Methods The hypertrophic scar of rabbits' ears was reproduced.At the 10th day after epithelization on the surface of wound,Ad-METH1 was injected into parts of scar tissue on different points.30 days later,changes of structure and ultrastructure of scar tissue of rabbits' ears were observed.Results At the 30th days after injection,HE deying of the hypertrophic scar of rabbits' ears showed that the distribution of micrangium declined distinctly.Ultrastructure revealed that endotheliocytes were tumefied and destructured,some blood vessels lost functions and proliferation and secretion of fibroblast reduced markedly.Conclusion Ad-METH1 has marked inhibitory function on the form of hypertrophic scar.Antiangiogenesis gene therapy could provide a new method to prevent and cure hypertrophic scar.