医学
癌症研究
癌症
血栓形成
免疫系统
免疫学
肿瘤微环境
转移
血管生成
作者
Xiaohong Ruby Xu,Dan Zhang,Brigitta Elaine Oswald,Naadiya Carrim,Xiaozhong Wang,Yan Hou,Qing Zhang,Christopher Lavalle,Thomas McKeown,Alexandra H. Marshall,Heyu Ni
标识
DOI:10.1080/10408363.2016.1200008
摘要
AbstractPlatelets are small anucleate blood cells generated from megakaryocytes in the bone marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet adhesion, activation and aggregation constitute the first wave of hemostasis. Blood coagulation, which is initiated by the intrinsic or extrinsic coagulation cascades, is the second wave of hemostasis. Activated platelets can also provide negatively-charged surfaces that harbor coagulation factors and markedly potentiate cell-based thrombin generation. Recently, deposition of plasma fibronectin, and likely other plasma proteins, onto the injured vessel wall has been identified as a new “protein wave of hemostasis” that may occur even earlier than the first wave of hemostasis, platelet accumulation. Although no experimental evidence currently exists, it is conceivable that platelets may also contribute to this protein wave of hemostasis by releasing their granule fibronectin and other proteins that may facilitate fibronect...
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