神经炎症
化学
渗透剂(生化)
药理学
炎症
有机化学
内科学
医学
作者
Magnus Pfaffenbach,Philippe Bolduc,Zhili Xin,Fang Gao,Ryan Evans,Terry Fang,J.V. Chodaparambil,Kate L. Henry,Pei Li,Steven Mathieu,C.M. Metrick,Jorge A. Vera Rebollar,Rong-Fang Gu,Christie-Ann McCarl,John Silbereis,Emily A. Peterson
标识
DOI:10.1021/acs.jmedchem.4c00560
摘要
Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases and cancer. We previously reported the development of a potent, selective, and brain-penetrant imidazopyrimidine series of IRAK4 inhibitors. However, lead molecule BIO-7488 (
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