二苯并呋喃
化学
生物合成
立体化学
酶
有机化学
作者
Daron E. Janzen,Jinge Zhou,Shu‐Ming Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-08-22
卷期号:25 (34): 6311-6316
标识
DOI:10.1021/acs.orglett.3c02234
摘要
p-Terphenyls contain a central benzene ring substituted with two phenyl residues at its para positions. Heterologous expression of a biosynthetic gene cluster from Aspergillus ustus led to the formation of four new p-terphenyl derivatives. Gene deletion experiments proved the formation and reductive dehydration of the terphenylquinone atromentin, followed by O-methylation and prenylation. Spontaneous dibenzofuran formation led to the final products. These results provide new insights into the biosynthesis of p-terphenyls in fungi and dibenzofuran formation in the biosynthesis of numerous natural products.
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