Anticoagulation in Phototherapy to Inhibit the Cancer-Associated Hypercoagulable State

The hypercoagulable state has challenged the lives of cancer patients, which is related to the treatment and the cancer-secreted procoagulant factors. Herein, a phototherapy system based on heparin modified Fe/Co-layered double hydroxide loading IR783 (LDH-hep-IR783) is established, which prevents the side effects and prothrombotic defect of the traditional treatment. The Fe/Co LDH is applied not only as the carrier of the photosensitizer but also can catalyze the decomposition of H 2 O 2 to overcoming the hypoxia of tumor microenvironment, enhancing the efficacy of photodynamic therapy (PDT) and decreasing the hypercoagulable state. The heparin plays as the stabilizer of the Fe/Co LDH nanosheet and also obviously inhibits the cancer associated hypercoagulable state of tumor-bearing mice. Therefore, the proposed strategy provides a promise insight for cancer therapy assisted by anticoagulated intervention.