Electrochemical Sensor Based on Au NPs@NiPc-Cu MOFs Modified Electrode for the Rapid Detection of Luteolin

In this study, a novel electrochemical sensor was designed to detect luteolin (Lu) with the composite of gold nanoparticles and nickel phthalocyanine-based 2D conductive metal-organic frameworks (Au NPs@NiPc-Cu MOFs) for the first time. The NiPc-Cu MOFs exhibit excellent conductivity, large specific surface area, and porous structure, which can accelerate the mass transfer process of target molecules. To further improve the sensitivity of the sensing platform, Au NPs with outstanding conductivity were introduced to the surface of NiPc-Cu MOFs to prepare Au NPs@NiPc-Cu MOFs. The synergistic effect of NiPc-Cu MOFs and Au NPs endows the sensor with excellent electrocatalytic performance and outstanding sensitivity. Under optimal conditions, the electrochemical sensor has a wide linear range (0.1–40 μ M). Moreover, the prepared sensor possesses good stability and anti-interference ability. This method does not require complicated sample pretreatment, simple operation, and short detection time, which can provide a new method for the rapid detection of Lu.