背外侧前额叶皮质
自杀意念
楔前
功能磁共振成像
心理学
扣带回前部
晚年抑郁症
前额叶皮质
额上回
神经科学
神经影像学
临床心理学
医学
毒物控制
自杀预防
认知
环境卫生
作者
Gaohong Lin,Ben Chen,Mingfeng Yang,Zhangying Wu,Kunliang Qiu,Min Zhang,Qiang Wang,Si Zhang,Jingyi Lao,Yijie Zeng,Yuping Ning,Xiaomei Zhong
标识
DOI:10.1016/j.jagp.2023.05.006
摘要
The dorsal lateral prefrontal cortex (DLPFC) has been identified as a neuromodulation target for alleviating suicidal ideation. Dysfunctional DLPFC has been implicated in suicidality in depression. This study aimed to investigate the functional connectivity (FC) of the DLPFC in late-life depression (LLD) with suicidal ideation.Resting-state functional magnetic resonance imaging (fMRI) data from 32 LLD patients with suicidal ideation (LLD-S), 41 LLD patients without suicidal ideation (LLD-NS), and 54 healthy older adults (HOA) were analyzed using DLPFC seed-based FC analyses. Group differences in FC were examined, and machine learning was applied to explore the potential of DLPFC-FC for classifying LLD-S from LLD-NS.Abnormal DLPFC-FC patterns were observed in LLD-S, characterized by lower connectivity with the angular gyrus, precuneus, and superior frontal gyrus compared to LLD-NS and healthy controls. A classification model based on the identified DLPFC-FC achieved an accuracy of 75%.The lower FC of DLPFC networks may contribute to the neurobiological mechanism of suicidal ideation in late-life depression. These findings may facilitate suicide prevention for LLD by providing potential neuroimaging markers and network-based neuromodulation targets. However, further confirmation with larger sample sizes and experimental designs is warranted.
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