Colon Polyp Surveillance - Separating the Wheat from the Chaff.

One goal of colorectal cancer (CRC) screening is to prevent CRC incidence by removing precancerous colonic polyps, which are detected in up to 50% of screening exams. Yet, the lifetime risk of CRC is 3.9-4.3%, so it is clear that most of these individuals with polyps would not develop CRC in their lifetime. It is therefore a challenge to determine which individuals with polyps will benefit from follow up, and at what intervals. There is some evidence that individuals with advanced polyps, based on size and histology, benefit from intensive surveillance. However, a large proportion of individuals will have small polyps without advanced histologic features (i.e., "non-advanced"), where the benefits of surveillance are uncertain and controversial. Demand for surveillance will further rise as more polyps are detected due to increased screening uptake, recent United States recommendations to expand screening to younger individuals, and the emergence of polyp detection technology. We review the current understanding and clinical implications of the natural history, biology, and outcomes associated with various categories of colon polyps based on size, histology, and number. Our aim is to highlight key knowledge gaps, specifically focusing on certain categories of polyps that may not be associated with future CRC risk, and provide insights to inform research priorities and potential management strategies. Optimization of CRC prevention programs based on updated knowledge about the future risks associated with various colon polyps is essential to ensure cost-effective screening and surveillance, wise utilization of resources, and inform efforts to personalize recommendations.