Fourier transform infrared spectroscopy used in drug excipients compatibility studies

Drug-excipient interaction/incompatibility is a major concern for drug stability and effectiveness. Assessing the compatibility of excipients is an essential phase in the formulation process for all pharmaceutical dosage forms. Incompatibility can be investigated using a variety of thermal and nonthermal approaches. Infrared spectroscopy can provide insights into potential intermolecular interactions between components by identifying specific vibrational modes that correspond to physico-chemical properties (chemical bonds and their strength) and molecular symmetry of a molecule. This article reviews some of the most relevant studies on Fourier Transform Infrared spectroscopy utilized as a tool for compatibility screening between 2017 and 2024.