Qingfei Jiedu Huatan Formula inhibits NLRP3 inflammasome activation to attenuates inflammation and pyroptosis in severe pneumonia: Integrating experimental verification, network pharmacology and transcriptomics

QJHF effectively attenuated the inflammatory response in severe pneumonia by inhibiting macrophage-mediated inflammation and NLRP3 inflammasome activation through TNF, NF-κB, and JAK/STAT signaling pathways.