Spontaneously Photocatalytic Nanoplatform for Sensitive Diagnosis and Penetrated Therapy of Cancer

In this study, a sensitive diagnosis and spontaneously photocatalytic therapy of cancer based on chemiluminescence (CL) and nanozyme was studied. Briefly, carbon nitride-supported copper nanoparticles (CuCNs) loaded with luminol (CuCN-L) were utilized to develop a microneedle patch (CuCN-L/MN). The CuCN-L probe could target overexpressed H₂O₂ in the TME and actively emit CL to achieve cancer cell imaging for diagnosis. In addition, 425 nm blue-violet CL could photocatalyze CuCN to reduce carbon dioxide (CO₂) to carbon monoxide (CO) for gas therapy (GT). Meanwhile, CuCN, acting as a photosensitizer (PS), could be activated by CL to produce reactive oxygen species (ROS), which realized photodynamic therapy (PDT). Furthermore, the use of a degradable MN based on hyaluronic acid (HA) promotes painless local administration as well as deep administration of GT and PDT. This technology of optical sensor-mediated anticancer treatment will have great potential to provide new inspirations for cancer diagnosis and therapy based on a self-excited nanoplatform.