An undescribed ferulic acid ester from Oreocome striata (DC.) Pimenov & Kljuykov and its anti-inflammatory activity

This study investigated the structural and anti-inflammatory properties of phenolic acids from Oreocome striata (DC.) Pimenov & Kljuykov. Phytochemical exploration yielded one undescribed ferulic acid ester - Oreocomeate A (1), along with eight known phenolic derivatives. Compound 1's 7'S,8'R configuration was assigned via combined spectroscopic analysis (HR-ESI-MS, NMR) and ECD calculations. Notably, compounds 2 and 4 were first reported as isolates from this plant family. In bioactivity evaluation, compound 1 exhibited the strongest NO inhibition with the IC₅₀ value of 15.71 ± 1.1 μM. Molecular docking models suggested potential interactions between compounds 1-9 and MT-ND target, indicating a mechanistic basis for their modulation of inflammatory pathway. These findings collectively identify phenolic acids as key bioactive constituents underlying CX's traditional anti-inflammatory applications.