医学
骨关节炎
过敏反应
双氯芬酸
嗜碱性粒细胞活化
过敏反应
麻醉
入射(几何)
过敏
不利影响
关节内
嗜碱性粒细胞
内科学
免疫学
免疫球蛋白E
病理
替代医学
物理
抗体
光学
作者
Tomohito Takeshige,Yasuhito Koyama,Yuta Hotchi,Kenji Kawai,Makiko Kohmaru,Takashi Akimoto,Junko Watanabe,Toshifumi Yae,Kenji Kido,Manabu Sugita,Kazuhisa Takahashi
摘要
ABSTRACT Osteoarthritis (OA) is a common condition. The treatment of knee OA aims to improve the quality of life and clinical symptoms, mainly knee pain. To develop a new treatment option, diclofenac etalhyaluronate (ONO-5704/SI-613; trade name: JOYCLU) was developed. Its anti-inflammatory and pain-relieving effects have been demonstrated. Conversely, adverse events have also been reported. Here, we report the case of a 71-year-old female who presented with anaphylaxis and prolonged allergic reactions after an intra-articular injection of JOYCLU. A basophil activation test (BAT) was performed to determine the cause of the anaphylaxis. BAT showed no positive findings. As the incidence of knee OA increases, the number of cases of JOYCLU use is expected to grow; therefore, careful administration is required. In this case, the cause was unknown by BAT. Thus, further development of appropriate testing methods is necessary. Intra-articular allergic reactions in knee OA may be modified and worsened besides normal allergic reactions; therefore, caution is required.
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