Oral Minoxidil Use in Yellow Nail Syndrome: Report of 2 Cases

Yellow Nail Syndrome (YNS) is rare disorder characterized by a triad of thickened yellow nails, primary lymphedema, and chronic respiratory manifestations. A key feature of the condition is diminished nail growth which contributes to the development of the characteristic yellow nails. Although its underlying etiology is unclear, it is postulated that microvasculopathy, lymphatic dysfunction, and protein leakage are involved. Current treatment options are limited and do not demonstrate consistent efficacy. Here we report two cases of YNS which improved with treatment using oral minoxidil for 3 - 6 months. To our knowledge, oral minoxidil for the treatment of YNS has not previously been reported.