One-pot (2 + 4) cycloaddition of propargyl alcohols with o-hydroxyphenyl substituted secondary phosphine oxides

inhibitory effect on the proliferation of MCF-7 human breast cancer cells. This reaction not only represents the first cycloaddition involving propargyl alcohols with phosphorus-containing dinucleophiles but also provides access to a class of potential biologically active P(V)-containing heterocycles.