A renal biopsy–anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes
作者
Francesca Conserva,Francesco Pesce,Claudia Cinefra,Tommaso Maria Marvulli,Ighli di Bari,Alessandra Stasi,Maria Felicia Faienza,Michele Rossini,Adriano Montinaro,Elena Squiccimarro,Giorgia Sclavo,Annalisa Schirinzi,Francesca Di Serio,Viji Nair,Damian Fermin,Rajasree Menon,Edgar A. Otto,Fabio Sallustio,Anna Gallone,Giovanni Stallone
We identify a genotype- and glucose-dependent mechanism regulating miR-27b-3p via AOPEP splicing and propose a biopsy-anchored, non-invasive biomarker panel (rs10761364, GA, miR-27b-3p) to differentiate DN from NDRD, supporting personalized nephrology care.
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(2025-6-4)
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