Graph-based EEG approach for depression prediction: integrating time-frequency complexity and spatial topology

Depression has become the prevailing global mental health concern. The accuracy of traditional depression diagnosis methods faces challenges due to diverse factors, making primary identification a complex task. Thus, the imperative lies in developing a method that fulfills objectivity and effectiveness criteria for depression identification. Current research underscores notable disparities in brain activity between individuals with depression and those without. The Electroencephalogram (EEG), as a biologically reflective and easily accessible signal, is widely used to diagnose depression. This article introduces an innovative depression prediction strategy that merges time-frequency complexity and electrode spatial topology to aid in depression diagnosis. Initially, time-frequency complexity and temporal features of the EEG signal are extracted to generate node features for a graph convolutional network. Subsequently, leveraging channel correlation, the brain network adjacency matrix is employed and calculated. The final depression classification is achieved by training and validating a graph convolutional network with graph node features and a brain network adjacency matrix based on channel correlation. The proposed strategy has been validated using two publicly available EEG datasets, MODMA and PRED+CT, achieving notable accuracy rates of 98.30 and 96.51%, respectively. These outcomes affirm the reliability and utility of our proposed strategy in predicting depression using EEG signals. Additionally, the findings substantiate the effectiveness of EEG time-frequency complexity characteristics as valuable biomarkers for depression prediction.