透明质酸
胶粘剂
伤口愈合
自愈水凝胶
生物医学工程
伤口敷料
组织工程
医学
高分子化学
化学
外科
材料科学
纳米技术
复合材料
解剖
图层(电子)
作者
Wanglin Duan,Xin Jin,Yiyang Zhao,Sergio Martín‐Saldaña,Shuaijun Li,Liang Qiao,Lu Shao,Bin Zhu,Shibo Hu,Furong Li,Feng Li,Yao Ma,Baoji Du,Lining Zhang,Yazhong Bu
标识
DOI:10.1016/j.carbpol.2024.122146
摘要
Diabetic wounds remain a global challenge due to disordered wound healing led by inflammation, infection, oxidative stress, and delayed proliferation. Therefore, an ideal wound dressing for diabetic wounds not only needs tissue adhesiveness, injectability, and self-healing properties but also needs a full regulation of the microenvironment. In this work, adhesive wound dressings (HA-DA/PRP) with injectability were fabricated by combining platelet rich plasma (PRP) and dopamine-modified-hyaluronic acid (HA-DA). The engineered wound dressings exhibited tissue adhesiveness, rapid self-healing, and shape adaptability, thereby enhancing stability and adaptability to irregular wounds. The in vitro experiments demonstrated that HA-DA/PRP adhesives significantly promoted fibroblast proliferation and migration, attributed to the loaded PRP. The adhesives showed antibacterial properties against both gram-positive and negative bacteria. Moreover, in vitro experiments confirmed that HA-DA/PRP adhesives effectively mitigated oxidative stress and inflammation. Finally, HA-DA/PRP accelerated the healing of diabetic wounds by inhibiting bacterial growth, promoting granulation tissue regeneration, accelerating neovascularization, facilitating collagen deposition, and modulating inflammation through inducing M1 to M2 polarization, in an in vivo model of infected diabetic wounds. Overall, HA-DA/PRP adhesives with the ability to comprehensively regulate the microenvironment in diabetic wounds may provide a novel approach to expedite the diabetic wounds healing in clinic.
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