化学
亲核细胞
试剂
芳基
烷基
组合化学
范围(计算机科学)
卤化物
反应中间体
催化作用
有机化学
联轴节(管道)
计算机科学
机械工程
工程类
程序设计语言
作者
David N. Primer,Gary A. Molander
摘要
The construction of quaternary centers is a common challenge in the synthesis of complex materials and natural products. Current cross-coupling strategies that can be generalized for setting these centers are sparse and, when known, are typically predicated on the use of reactive organometallic reagents. To address this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is reported. In addition to details on the cross-coupling scope and limitations, full screening efforts and mechanistic experiments are communicated.
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