猴头菌
多糖
伞菌纲
菌丝体
蘑菇
微生物学
香菇属
药用真菌
灵芝
生物
传统医学
擔子菌門
生物化学
医学
食品科学
生态学
植物
原材料
作者
Mingxing Wang,Yanqiu Zhang,Xulang Xiao,Dakang Xu,Yang Gao,Qian Gao
出处
期刊:International Journal of Medicinal Mushrooms
日期:2017-01-01
卷期号:19 (12): 1053-1060
被引量:8
标识
DOI:10.1615/intjmedmushrooms.2017024975
摘要
Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H. erinaceus a polysaccharide with anti-gastric ulcer and antigastritis activity, but its effects on gastric malignancy have not been elucidated. We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N'-nitro-N-nitrosoguanidine. We observed that the polysaccharide potently induced cell apoptosis and cell cycle arrest at the G0/G1 phase in the MC cell line but did not have any effect on the GES-1 cell line at the same doses. Further mechanistic studies revealed that the polysaccharide exerted its activity through an apoptosis-associated pathway by modulating the expression of Bax, Bcl-2, and caspase-3. Differential effects of the polysaccharide on the GES-1 and MC cell lines indicate that the polysaccharide was effective in preventing gastric cancer progression.
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