细胞凋亡
癌症研究
癌症
小RNA
程序性细胞死亡
医学
生物
基因
生物信息学
内科学
遗传学
作者
Xialu Feng,Chen Zhang,Yan Yang,Deren Hou,Anding Zhu
出处
期刊:Advances in Clinical and Experimental Medicine
[Wroclaw Medical University]
日期:2018-02-28
卷期号:27 (2): 263-270
被引量:14
摘要
It has been recognized that miR-181a expression is dysregulated and intimately associated with clinical prognosis in a variety of human cancers. However, the direct role of miR-181a in tumor progression has been elusive. Moreover, mounting evidence has demonstrated that cellular apoptosis, a physiological process of programmed cell death, is disrupted in various categories of human malignancies. Multiple apoptosisrelated genes have been proven to act as the target genes of miR-181a. In this study, we hypothesize that miR-181a probably plays a potential role in modulating the procession and apoptosis of cancer cells. We performed a literature review and elucidated how miR-181a modulated cellular apoptosis, especially the malignant neoplasm cells. We also unraveled the potential role of miR-181a in the diagnosis, treatment and clinical prognosis of multiple human malignancies – miR-181a plays a pivotal role in the development, treatment and prognosis of patients suffering from malignant tumors. It also participates in the development of cancer partially by modulating cellular apoptosis.
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