偏头痛
癫痫
家族性偏瘫性偏头痛
神经科学
疾病
病态的
病理生理学
神经系统疾病
机制(生物学)
医学
心理学
中枢神经系统疾病
精神科
先兆偏头痛
病理
光环
哲学
认识论
作者
Massimo Mantegazza,Sandrine Cestèle
标识
DOI:10.1016/j.neulet.2017.11.025
摘要
Migraine and epilepsy are episodic disorders with distinct features, but they have some clinical and pathophysiological overlaps. We review here clinical overlaps between seizures and migraine attacks, activities of neuronal networks observed during seizures and migraine attacks, and molecular and cellular mechanisms of migraine identified in genetic forms, focusing on genetic variants identified in hemiplegic migraine and their functional effects. Epilepsy and migraine can be generated by dysfunctions of the same neuronal networks, but these dysfunctions can be disease-specific, even if pathogenic mutations target the same protein. Studies of rare monogenic forms have allowed the identification of some molecular/cellular dysfunctions that provide a window on pathological mechanisms: we have begun to disclose the tip of the iceberg.
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