生物制造
光养
生化工程
异养
合成生物学
环境科学
生物技术
生物
细菌
工程类
生物信息学
遗传学
作者
Hao Gao,Clarisse Manishimwe,Lu Yang,Hanxiao Wang,Yujia Jiang,Wankui Jiang,Wenming Zhang,Fengxue Xin,Min Jiang
标识
DOI:10.1016/j.biortech.2022.126954
摘要
Synthetic microbial consortia provide a versatile and efficient platform for biochemicals production through the labor division. Especially, microbial communities composed of phototrophs and heterotrophs offer a promising alternative, as they can directly convert carbon dioxide (CO2) into chemicals. Within this system, photoautotrophic microbes can convert CO2 into organic carbon for microbial growth and metabolites synthesis by the heterotrophic partners. In return, heterotrophs can provide additional CO2 to support the growth of photoautotrophic microbes. However, the unmatched growing conditions, low stability and production efficiency of synthetic microbial consortia hinder their further applications. Thus, design and construction of mutualistic and stable synthetic light-driven microbial consortia are urgently needed. In this review, the progress of synthetic light-driven microbial consortia for chemicals production was comprehensively summarized. In addition, space-efficient synthetic light-driven microbial consortia in hydrogel system were reviewed. Perspectives on orderly distribution of light-driven microbial consortia associated with 3D printing technology in biomanufacturing were also addressed.
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