乳酸脱氢酶
骨骼肌
内分泌学
内科学
辅活化剂
平衡
雌激素受体
受体
葡萄糖稳态
生物
心理压抑
转录因子
过氧化物酶体增殖物激活受体
化学
生物化学
基因表达
酶
医学
胰岛素抵抗
基因
胰岛素
癌症
乳腺癌
作者
Serge Summermatter,Gesa Santos,Joaquín Pérez-Schindler,Christoph Handschin
标识
DOI:10.1073/pnas.1212976110
摘要
The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) controls metabolic adaptations. We now show that PGC-1α in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-α-dependent manner. Concomitantly, PGC-1α reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1α thereby coordinately alters the composition of the LDH complex and prevents the increase in blood lactate during exercise. Our results show how PGC-1α actively coordinates lactate homeostasis and provide a unique molecular explanation for PGC-1α-mediated muscle adaptations to training that ultimately enhance exercise performance and improve metabolic health.
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