糖基化
内吞循环
CD36
细胞生物学
化学
脂肪生成
3T3-L1
3T3电池
内科学
生物化学
生物
内吞作用
细胞
脂肪组织
医学
转染
受体
基因
作者
Akihiko Kuniyasu,Nobutaka Ohgami,Shigeki Hayashi,Akira Miyazaki,Seikoh Horiuchi,Hitoshi Nakayama
出处
期刊:FEBS Letters
[Wiley]
日期:2003-02-07
卷期号:537 (1-3): 85-90
被引量:92
标识
DOI:10.1016/s0014-5793(03)00096-6
摘要
Interaction of advanced glycation end products (AGE) with AGE receptors induces several cellular phenomena potentially relating to diabetic complications. We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and subsequent degradation of [(125)I]AGE-BSA, which were inhibited effectively by the anti-CD36 antibody. Ligand specificity of CD36 for modified BSAs was compared with that of LOX-1 and scavenger receptor class A. Effect of fucoidan on [(125)I]AGE-BSA binding showed a sharp contrast to that on [(125)I]-oxidized low density lipoprotein. These results implicate that CD36-mediated interaction of AGE-modified proteins with adipocytes might play a pathological role in obesity or insulin-resistance.
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