Chiral Copper Amide Catalyzed Asymmetric Mannich‐Type Reactions of Glycine Schiff Bases

Chiral copper amide: A copper hexamethyldisilazide (CuHMDS) complex with (R)-DTBM-SEGPHOS is a chiral Brønsted-base catalyst for asymmetric Mannich-type reactions of a glycine Schiff base with tosylimines. The reactions proceed smoothly to afford the desired adducts in good to high yields and high stereoselectivities. The chiral CuHMDS/(R)-DTBM-SEGPHOS complex could be prepared only in situ; isolated CuHMDS was not a suitable catalyst. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.