医学
肝细胞癌
非酒精性脂肪肝
脂肪肝
肝硬化
肝癌
内科学
无症状的
脂肪性肝炎
肥胖
胃肠病学
人口
疾病
肝病
2型糖尿病
癌症
糖尿病
内分泌学
环境卫生
作者
Arianna Marengo,Chiara Rosso,Elisabetta Bugianesi
出处
期刊:Annual Review of Medicine
[Annual Reviews]
日期:2016-01-14
卷期号:67 (1): 103-117
被引量:507
标识
DOI:10.1146/annurev-med-090514-013832
摘要
The burden of hepatocellular carcinoma (HCC), the most common form of liver cancer, is steadily growing because obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD) are replacing viral- and alcohol-related liver disease as major pathogenic promoters. The most worrisome aspects of these new risk factors are their large spread in the general population and their link with HCC arising in noncirrhotic livers. HCC may be the presenting feature of an asymptomatic nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD. The HCC risk connected to metabolic factors has been underestimated so far, and a poorer surveillance has prevented an adequate treatment. Systemic and hepatic molecular mechanisms involved in obesity- and NAFLD-induced hepatocarcinogenesis as well as potential early markers of HCC are being extensively investigated. This review summarizes current evidence linking obesity, NAFLD and liver cancer, discusses its clinical impact and describes the main mechanisms underlying this complex relationship.
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