Colorimetric and Fluorometric Detection of Nucleic Acids Using Cationic Polythiophene Derivatives

Different electrostatic interactions and conformational structures between single- or double-stranded negatively charged nucleic acids bound to a surface (see picture) and water-soluble cationic poly(3-alkoxy-4-methylthiophene) derivatives (in yellow) provide the basis for a sensitive optical detection method (colorimetric or fluorometric) for oligonucleotide hybridization. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z18191_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.