雌激素相关受体α
雌激素受体
雌激素
受体
核受体
生物
雌激素受体α
雌激素相关受体γ
雌激素受体
相关性(法律)
神经科学
生物信息学
计算生物学
内分泌学
遗传学
基因
癌症
转录因子
政治学
乳腺癌
法学
作者
Pierre-Luc Bardet,Vincent Laudet,Jean‐Marc Vanacker
标识
DOI:10.1016/j.tem.2006.03.005
摘要
Through studies in mammalian model systems, the estrogen-receptor-related receptor (ERR) alpha, an orphan nuclear receptor, has been shown to interfere with estrogen signaling and might therefore be an interesting pharmaceutical target in estrogen-related diseases. ERRalpha is also involved in energy storage and consumption, and its modulation might be of relevance in the treatment of obesity and diabetes. Recent data have also been published on the effects of this receptor, as well as other members of the ERR family, in non-mammalian animal model systems. Besides indications concerning their mechanisms of action, this analysis demonstrated a role for ERRalpha in controlling cellular movements, and suggested that ERRs might be implicated in a more subtle range of processes than originally envisioned.
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