丝绸
生物相容性
固定(群体遗传学)
骨愈合
材料科学
颅面
生物医学工程
应力屏蔽
骨折
丝素
牙科
植入
医学
外科
复合材料
人口
冶金
放射科
精神科
环境卫生
作者
Gabriel S. Perrone,Gary G. Leisk,Tim J. Lo,Jodie E. Moreau,Dylan S. Haas,Bernke J. Papenburg,Ethan Golden,Benjamin P. Partlow,Sharon Fox,Ahmed M. S. Ibrahim,Samuel J. Lin,David L. Kaplan
摘要
Metallic fixation systems are currently the gold standard for fracture fixation but have problems including stress shielding, palpability and temperature sensitivity. Recently, resorbable systems have gained interest because they avoid removal and may improve bone remodelling due to the lack of stress shielding. However, their use is limited to paediatric craniofacial procedures mainly due to the laborious implantation requirements. Here we prepare and characterize a new family of resorbable screws prepared from silk fibroin for craniofacial fracture repair. In vivo assessment in rat femurs shows the screws to be self-tapping, remain fixed in the bone for 4 and 8 weeks, exhibit biocompatibility and promote bone remodelling. The silk-based devices compare favourably with current poly-lactic-co-glycolic acid fixation systems, however, silk-based devices offer numerous advantages including ease of implantation, conformal fit to the repair site, sterilization by autoclaving and minimal inflammatory response.
科研通智能强力驱动
Strongly Powered by AbleSci AI